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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for pragmatic trials to be valid and to reduce bias in the results, is also necessary. Too much heterogeneity, however could cause issues with the design of the trial.
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The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually ordered by policymakers and practitioners to help inform their decisions. They can also be used to assess the causality of an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation trials.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, and monitoring.
프라그마틱 슬롯 팁 of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary-care settings.